| Date: | 31 May – 5 June |
| Edition: | 19th |
| Category: | ITF Women's Circuit |
| Location: | Marseille, France |
| Prize Money: | $100,000 |
| Champs: |  Danka Kovinić |
| Champd: | Hsieh Su-wei /  Nicole Melichar |
The 2016 Open Féminin de Marseille was a professional tennis tournament played on outdoor clay courts. It was the nineteenth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $100,000 in prize money. It took place in Marseille, France, on 31 May – 5 June 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Montenegro | Danka Kovinić | 59 | 1 | |
| Hsieh Su-wei | 80 | 2 | ||
 Spain | Lara Arruabarrena | 92 | 3 | |
| Spain | Lourdes Domínguez Lino | 112 | 4 | |
| Maria Sakkari | 114 | 5 | ||
 China | Han Xinyun | 125 | 6 | |
| Spain | Sílvia Soler Espinosa | 126 | 7 | |
 Romania | Alexandra Dulgheru | 127 | 8 |
The following player received a wildcard into the singles main draw:
Victoria Larrière Victoria Muntean Irina Ramialison Caroline RoméoThe following players received entry from the qualifying draw:
The following player received entry by a protected ranking:
See main article: 2016 Open Féminin de Marseille – Singles.
Danka Kovinić def. Hsieh Su-wei, 6–2, 6–3 Nicole Melichar def. 
Jana Čepelová / Lourdes Domínguez Lino, 1–6, 6–3, [10–3]
