| Date: | 9–15 May |
| Edition: | 20th |
| Category: | ITF Women's Circuit |
| Location: | Saint-Gaudens, France |
| Prize Money: | $50,000+H |
| Champs: |  Irina Khromacheva |
| Champd: | Demi Schuurs /  Renata Voráčová |
| After Name: | Engie Open Saint-Gaudens Occitanie |
The 2016 Open Engie Saint-Gaudens Midi-Pyrénées was a professional tennis tournament played on outdoor clay courts. It was the twentieth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $50,000+H in prize money. It took place in Saint-Gaudens, France, on 9–15 May 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Lourdes Domínguez Lino | 111 | 1 | |
| Maria Sakkari | 117 | 2 | ||
 Austria | Tamira Paszek | 124 | 3 | |
| Viktorija Golubic | 132 | 4 | ||
 Japan | Miyu Kato | 146 | 6 | |
 Belgium | Ysaline Bonaventure | 148 | 7 | |
| Amra Sadiković | 151 | 8 |
The following players received wildcards into the singles main draw:
Deniz Khazaniuk Ariadna Martí Riembau
Victoria Muntean Emmanuelle SalasThe following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot:
The following player received entry by a protected ranking:
See main article: 2016 Open Engie Saint-Gaudens Midi-Pyrénées – Singles.
Irina Khromacheva def. Maria Sakkari, 1–6, 7–6(7–3), 6–1See main article: 2016 Open Engie Saint-Gaudens Midi-Pyrénées – Doubles.
Renata Voráčová def. Nicola Geuer / Viktorija Golubic, 6–1, 6–2
