| Champ: |  Nick Kyrgios |
| Runner: | Marin Čilić |
| Score: | 6–2, 7–6(7–3) |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Open 13 – Singles |
| Main Name: | Open 13 |
See main article: 2016 Open 13 Provence.
Gilles Simon was the defending champion, but lost in the first round to Teymuraz Gabashvili.
Nick Kyrgios won his first ATP title, defeating Marin Čilić in the final, 6–2, 7–6(7–3).
The top four seeds receive a bye into the second round.
