| Champ: |  Lucas Pouille |
| Runner: |  Dominic Thiem |
| Score: | 7–6(7–5), 6–2 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: article and 2016 Moselle Open.
Jo-Wilfried Tsonga was the defending champion, but withdrew with a left knee injury before the tournament began.
Lucas Pouille won the title, defeating Dominic Thiem in the final, 7–6(7–5), 6–2.
The top four seeds receive a bye into the second round.