| Date: | 19–25 September |
| Edition: | 14th |
| Surface: | Indoor hard court |
| Draw: | 28S / 16D |
| Location: | Metz, France |
| Champs: |  Lucas Pouille |
| Champd: | Julio Peralta /  Horacio Zeballos |
The 2016 Moselle Open was a men's tennis tournament held in Metz, France and played on indoor hard courts. It was the 14th edition of the Moselle Open, and part of the ATP World Tour 250 series of the 2016 ATP World Tour. It was held at the Arènes de Metz from 19 September to 25 September 2016. Third-seeded Lucas Pouille won the singles title.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Austria | Dominic Thiem | 10 | 1 | |
 Belgium | David Goffin | 14 | 2 | |
| France | Lucas Pouille | 18 | 3 | |
| France | Gilles Simon | 28 | 4 | |
 Slovakia | Martin Kližan | 31 | 5 | |
 Luxembourg | Gilles Müller | 37 | 6 | |
| France | Benoît Paire | 38 | 7 | |
| France | Nicolas Mahut | 40 | 8 |
The following players received wild cards into the singles main draw:
The following players received entry from the singles qualifying draw:
Carlos Berlocq →replaced by Jan-Lennard Struff
Marcel Granollers →replaced by Dustin Brown Íñigo Cervantes Guido Pella →replaced by Pierre-Hugues Herbert Jo-Wilfried Tsonga (left knee injury) →replaced by Ivan Dodig| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| France | Julien Benneteau | France | Édouard Roger-Vasselin | 50 | 1 | |
| Austria | Oliver Marach | France | Fabrice Martin | 65 | 2 | |
| Mate Pavić |  New Zealand | Michael Venus | 76 | 3 | ||
 Sweden | Robert Lindstedt |  Pakistan | Aisam-ul-Haq Qureshi | 79 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2016 Moselle Open – Singles.
Lucas Pouille defeated Dominic Thiem, 7–6(7–5), 6–2See main article: 2016 Moselle Open – Doubles.
Horacio Zeballos defeated Mate Pavić / Michael Venus, 6–3, 7–6(7–4)