| Date: | 15–21 February |
| Edition: | 3rd (men) 2nd (women) |
| Draw: | 32S / 32Q / 16D |
| Surface: | Hard |
| Prize Money: | $50,000+H (men) $25,000 (women) |
| Location: | Cuernavaca, Mexico |
| Champms: |  Gerald Melzer |
| Champmd: |  Philip Bester / Peter Polansky |
| Champws: |  Marie Bouzková |
| Champwd: | Aleksandrina Naydenova /  Fanny Stollár |
The 2016 Morelos Open was a professional tennis tournament played on outdoor hard courts. It was the third (ATP) and second (ITF) editions of the tournament, which was part of the 2016 ATP Challenger Tour and the 2016 ITF Women's Circuit, offering prize money of $50,000 (ATP) and $25,000 (ITF) on 15–21 February 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Dominican Republic | Víctor Estrella Burgos | 56 | 1 | |
 Argentina | Horacio Zeballos | 119 | 2 | |
| Austria | Gerald Melzer | 134 | 3 | |
 Colombia | Alejandro González | 156 | 4 | |
 Spain | Adrián Menéndez-Maceiras | 160 | 5 | |
 United States | Alexander Sarkissian | 182 | 6 | |
| Austria | Dennis Novak | 205 | 7 | |
| Spain | Jordi Samper-Montaña | 213 | 8 |
The following players received wildcards into the singles main draw:
Mauricio Astorga Lucas Gómez Tigre Hank Luis PatiñoThe following players gained entry into the singles main draw as an alternate:
The following player gained entry into the singles main draw as a lucky loser:
The following players received entry from the qualifying draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Belgium | An-Sophie Mestach | 151 | 1 | |
| Mexico | Victoria Rodríguez | 245 | 2 | |
 Venezuela, Bolivarian Republic of | Andrea Gámiz | 256 | 3 | |
| Indy de Vroome | 259 | 4 | ||
 Ukraine | Elizaveta Ianchuk | 274 | 5 | |
 Japan | Ayaka Okuno | 288 | 6 | |
 China | Xu Shilin | 307 | 7 | |
| Aleksandrina Naydenova | 322 | 8 |
The following players received wildcards into the singles main draw:
Alexia Coutiño Castillo Beatriz Magdalena Flores Daniela Morales Beckmann María José Portillo RamírezThe following players received entry from the qualifying draw:
Nicole Coopersmith
Jaqueline Cristian Elizaveta Ianchuk Madeleine Kobelt
Nika Kukharchuk Evgeniya Levashova Zoë Gwen ScandalisThe following player received entry by a lucky loser spot:
Shelby TalcottSee main article: 2016 Morelos Open – Men's singles.
Gerald Melzer def. Alejandro González, 7–6(7–4), 6–3 Marie Bouzková def. Lauren Albanese, 0–6, 6–0, 6–1See main article: 2016 Morelos Open – Men's doubles.
Philip Bester / Peter Polansky def. Marcelo Arévalo / 
Sergio Galdós, 6–4, 3–6, [10–6] Fanny Stollár def. Elizaveta Ianchuk / Kateřina Kramperová, 6–3, 6–2
