| Champ: |  Pierre-Hugues Herbert Nicolas Mahut |
| Runner: |  Jamie Murray Bruno Soares |
| Score: | 4–6, 6–0, [10–6] |
| Type: | singles doubles |
See main article: 2016 Monte-Carlo Rolex Masters.
Bob and Mike Bryan were the two-time defending champions, but lost in the second round to Juan Sebastián Cabal and Robert Farah.
Pierre-Hugues Herbert and Nicolas Mahut won the title, defeating Jamie Murray and Bruno Soares in the final, 4–6, 6–0, [10–6].
All seeds received a bye into the second round.