| Champ: |  Dominic Thiem |
| Runner: | Philipp Kohlschreiber |
| Score: | 6–7(2–7), 6–4, 6–4 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| Main Name: | Stuttgart Open |
See main article: article and 2016 MercedesCup. Rafael Nadal was the defending champion, but chose not to participate this year.
Dominic Thiem won the title, defeating Philipp Kohlschreiber in the final, 6–7(2–7), 6–4, 6–4.[1]
The top four seeds receive a bye into the second round.