| Champ: | Ivo Karlović |
| Runner: |  Feliciano López |
| Score: | 7–6(7–5), 6–2 |
| Draw: | 28 |
| Seeds: | 8 |
| Edition: | 1st |
| Type: | singles doubles |
See main article: article and 2016 Los Cabos Open. This was the first edition of the tournament.
Ivo Karlović won the title, defeating Feliciano López in the final, 7–6(7–5), 6–2.
The top four seeds receive a bye into the second round.