| Champ: |  Svetlana Kuznetsova |
| Runner: |  Daria Gavrilova |
| Score: | 6–2, 6–1 |
| Seeds: | 8 |
See main article: article and 2016 Kremlin Cup. Svetlana Kuznetsova was the defending champion and successfully defended her title, defeating Daria Gavrilova in the final, 6–2, 6–1.
By claiming the title, Kuznetsova became the final qualifier for the 2016 WTA Finals, overtaking Johanna Konta on the race list.
The top four seeds received a bye into the second round.