| Champ: |  Pablo Carreño Busta |
| Runner: |  Fabio Fognini |
| Score: | 4–6, 6–3, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Before Name: | Kremlin Cup – Men's singles |
| After Name: | Kremlin Cup – Men's singles |
See main article: article and 2016 Kremlin Cup.
Marin Čilić was the two-time defending champion, but chose not to participate this year.
Pablo Carreño Busta won the title, defeating Fabio Fognini in the final, 4–6, 6–3, 6–2.
The top four seeds receive a bye into the second round.