The 2016 Istanbul Open (also known as the TEB BNP Paribas Istanbul Open for sponsorship purposes) was a men's tennis tournament played on outdoor clay courts. It was the second edition of the Istanbul Open, and an ATP World Tour 250 event. It took place at the Koza World of Sports Arena in Istanbul, Turkey, from 25 April until 1 May 2016. Unseeded Diego Schwartzman won the singles title.
See main article: 2016 Istanbul Open – Singles. 
Diego Schwartzman defeated Grigor Dimitrov, 6–7(5–7), 7–6(7–4), 6–0
See main article: 2016 Istanbul Open – Doubles. 
Flavio Cipolla / 
Dudi Sela defeated Andrés Molteni / Diego Schwartzman, 6–3, 5–7, [10–7]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Bernard Tomic | 21 | 1 | |
| Grigor Dimitrov | 28 | 2 | ||
| Ivo Karlović | 29 | 3 | ||
| Argentina | Federico Delbonis | 40 | 4 | |
 Spain | Marcel Granollers | 50 | 5 | |
 Czech Republic | Jiří Veselý | 53 | 6 | |
 Russian Federation | Teymuraz Gabashvili | 54 | 7 | |
| Spain | Albert Ramos-Viñolas | 55 | 8 |
The following players received wildcards into the main draw:
The following players received entry via the qualifying draw:
The following player received entry as a lucky loser:
Juan Mónaco → replaced by 
Filip Krajinović 
Lucas Pouille → replaced by Máximo González
Rajeev Ram → replaced by Facundo Bagnis| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 United Kingdom | Dominic Inglot |  Sweden | Robert Lindstedt | 59 | 1 | |
| United States | Nicholas Monroe | Mate Pavić | 88 | 2 | ||
| Argentina | Guillermo Durán | Argentina | Máximo González | 103 | 3 | |
| Wesley Koolhof | Matwé Middelkoop | 114 | 4 |
The following pairs received wildcards into the doubles main draw:
Robert Lindstedt (abdominal injury) Adrian Mannarino (hip injury)
