The 2016 Intrust Super Premiership season consists of 25 regular season round starting on Saturday, March 5, 2016, and ending on Saturday, 24 September 2016 with the Grand Final
| Home | Score | Away | Date | Venue | |
|---|---|---|---|---|---|
| Mount Prichard Mounties | 26-24 | Penrith Panthers | March 5, 2016 | GIO Stadium | |
| Wests Tigers | 34-16 | Manly-Warringah Sea Eagles | March 5, 2016 | Campbelltown Stadium | |
| Newtown Jets | 16-16 | Canterbury-Bankstown Bulldogs | March 5, 2016 | Henson Park | |
| Illawarra Cutters | 36-22 | New Zealand Warriors | March 5, 2016 | WIN Stadium | |
| Newcastle Knights | 12-28 | North Sydney Bears | March 6, 2016 | Kurri Sports Ground | |
| Wentworthville Magpies | 28-18 | Wyong Roos | March 6, 2016 | Ringrose Park |