| Date: | 4 – 10 July |
| Edition: | 10th |
| Category: | ATP Challenger Tour |
| Prize Money: | €42,500+H |
| Surface: | Clay |
| Location: | Todi, Italy |
| Champs: |  Miljan Zekić |
| Champd: |  Marcelo Demoliner / Fabrício Neis |
| Before Name: | Distal & ITR Group Tennis Cup |
The 2016 Internazionali di Tennis dell'Umbria is a professional tennis tournament played on clay courts. It is the 10th edition of the men's tournament which is part of the 2016 ATP Challenger Tour, offering a total of €42,500+H in prize money. The event will take place at the Tennis Club Todi in Todi, Italy, on 4 – 10 July 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovakia | Andrej Martin | 105 | 1 | |
 Italy | Marco Cecchinato | 130 | 2 | |
 Argentina | Marco Trungelliti | 150 | 3 | |
 Hungary | Márton Fucsovics | 163 | 4 | |
| Italy | Alessandro Giannessi | 164 | 5 | |
| Italy | Luca Vanni | 171 | 6 | |
| Argentina | Facundo Argüello | 175 | 7 | |
 Turkey | Marsel İlhan | 180 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2016 Internazionali di Tennis dell'Umbria – Singles.
Miljan Zekić def. Stefano Napolitano, 6–7(6–8), 6–4, 6–3See main article: 2016 Internazionali di Tennis dell'Umbria – Doubles.
Marcelo Demoliner / Fabrício Neis def. Salvatore Caruso / Alessandro Giannessi, 6–1, 3–6, [10–5]
