| Date: | 7–13 November |
| Edition: | 4th |
| Surface: | Hard |
| Location: | Mouilleron-le-Captif, France |
| Champs: |  Julien Benneteau |
| Champd: | Jonathan Eysseric / Édouard Roger-Vasselin |
The 2016 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts. It was the fourth edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 7 and 13 November 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Benoît Paire | 45 | 1 | |
 Russian Federation | Mikhail Youzhny | 51 | 2 | |
| France | Paul-Henri Mathieu | 67 | 3 | |
| Russian Federation | Konstantin Kravchuk | 79 | 4 | |
 Moldova, Republic of | Radu Albot | 99 | 5 | |
 Georgia | Nikoloz Basilashvili | 101 | 6 | |
| Marco Chiudinelli | 116 | 7 | ||
| Tobias Kamke | 121 | 8 |
The following players received wildcards into the singles main draw:
The following player entered the main draw using a special exemption:
The following players received entry from the qualifying draw:
See main article: 2016 Internationaux de Tennis de Vendée – Singles.
Julien Benneteau def. Andrey Rublev, 7–5, 2–6, 6–3.See main article: 2016 Internationaux de Tennis de Vendée – Doubles.
Jonathan Eysseric / Édouard Roger-Vasselin def. 
Johan Brunström / Andreas Siljeström 6–7(1–7), 7–6(7–3), [11–9].