| Date: | 18–24 April |
| Edition: | 16th |
| Category: | ITF Women's Circuit |
| Location: | Dothan, Alabama, United States |
| Prize Money: | $50,000 |
| Champs: |  Rebecca Peterson |
| Champd: |  Asia Muhammad / Taylor Townsend |
The 2016 Hardee's Pro Classic was a professional tennis tournament played on outdoor clay courts. It was the sixteenth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $50,000 in prize money. It took place in Dothan, Alabama, United States, on 18–24 April 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Anna Tatishvili | 115 | 1 | |
| Sweden | Rebecca Peterson | 134 | 2 | |
 Russian Federation | Alexandra Panova | 155 | 3 | |
| United States | Jessica Pegula | 159 | 4 | |
 Belgium | Elise Mertens | 162 | 5 | |
| United States | Sachia Vickery | 175 | 6 | |
| United States | Julia Boserup | 178 | 7 | |
| United States | Katerina Stewart | 180 | 8 |
The following players received wildcards into the singles main draw:
Lauren Albanese Sofia Kenin Claire Liu Alexandra SanfordThe following players received entry from the qualifying draw:
Varvara Flink
Olga Ianchuk Raveena Kingsley Taylor TownsendThe following player received entry by a lucky loser:
The following player received entry by a protected ranking:
See main article: 2016 Hardee's Pro Classic – Singles.
Rebecca Peterson def. Taylor Townsend, 6–4, 6–2See main article: 2016 Hardee's Pro Classic – Doubles.
Asia Muhammad / Taylor Townsend def. Caitlin Whoriskey / Keri Wong, 6–0, 6–1
