| Date: | 2–8 May |
| Edition: | 19th |
| Category: | ITF Women's Circuit |
| Location: | Cagnes-sur-Mer, France |
| Prize Money: | $100,000 |
| Champs: |  Magda Linette |
| Champd: |  Andreea Mitu / Demi Schuurs |
| Before Name: | Open GDF Suez de Cagnes-sur-Mer Alpes-Maritimes |
| After Name: | Open de Cagnes-sur-Mer Alpes-Maritimes |
The 2016 Engie Open de Cagnes-sur-Mer Alpes-Maritimes was a professional tennis tournament played on outdoor clay courts. It was the nineteenth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $100,000 in prize money. It took place in Cagnes-sur-Mer, France, on 2–8 May 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Carina Witthöft | 85 | 1 | ||
 Kazakhstan | Zarina Diyas | 94 | 2 | |
 France | Pauline Parmentier | 102 | 3 | |
| Poland | Magda Linette | 104 | 4 | |
| Stefanie Vögele | 105 | 5 | ||
| Tatjana Maria | 107 | 6 | ||
| Romania | Andreea Mitu | 110 | 7 | |
 Russian Federation | Elizaveta Kulichkova | 114 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry by a lucky loser spot:
Beatriz Haddad Maia Anaïs van CauterSee main article: 2016 Engie Open de Cagnes-sur-Mer Alpes-Maritimes – Singles.
Magda Linette def. Carina Witthöft, 6–3, 7–5See main article: 2016 Engie Open de Cagnes-sur-Mer Alpes-Maritimes – Doubles.
Andreea Mitu / Demi Schuurs def. Xenia Knoll / 
Aleksandra Krunić, 6–4, 7–5
