| Date: | 25–31 January |
| Edition: | 6th |
| Category: | ITF Women's Circuit |
| Location: | Andrézieux-Bouthéon, France |
| Surface: | Hard / Indoor |
| Prize Money: | $50,000 |
| Champs: | Stefanie Vögele |
| Champd: |  Elise Mertens / An-Sophie Mestach |
| After Name: | Engie Open Andrézieux-Bouthéon 42 |
The 2016 Engie Open Métropole 42 was a professional tennis tournament played on indoor hard courts. It was the sixth edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $50,000 in prize money. It took place in Andrézieux-Bouthéon, France, on 25–31 January 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Romania | Andreea Mitu | 96 | 1 | |
| Stefanie Vögele | 118 | 2 | ||
| Romina Oprandi | 124 | 3 | ||
 Czech Republic | Tereza Smitková | 131 | 4 | |
 Turkey | Çağla Büyükakçay | 134 | 5 | |
 Ukraine | Maryna Zanevska | 146 | 6 | |
 France | Océane Dodin | 147 | 7 | |
| Petra Martić | 148 | 8 |
The following players received wildcards into the singles main draw:
Myrtille Georges Shérazad Reix Caroline Roméo Carla ToulyThe following players received entry from the qualifying draw:
The following player received entry using a junior exempt:
See main article: 2016 Engie Open Métropole 42 – Singles.
An-Sophie Mestach, 6–1, 6–2See main article: 2016 Engie Open Métropole 42 – Doubles.
Elise Mertens / An-Sophie Mestach def. Viktorija Golubic / Xenia Knoll, 6–4, 3–6, [10–7]
