| Season: | 2016 |
| Matches: | 112 |
| Nextseason: | 2017 |
División de Honor de Béisbol 2016 was the 31st season of the top Spanish baseball league since its establishment. It started on 2 April and finished on 31 July.
Valencia Astros achieved its first title.
| Team | Stadium | Capacity | City/Area | |
|---|---|---|---|---|
| Tenerife Marlins | Centro Insular de Béisbol | 200 | Puerto de la Cruz, Tenerife | |
| Astros Valencia | Campo Federativo del Turia | 100 | Valencia | |
| Sant Boi | Campo Municipal de Béisbol | 500 | Sant Boi de Llobregat | |
| Barcelona | Camp Municipal Carlos Pérez de Rozas | 800 | Barcelona | |
| San Inazio Bilbao Bizkaia | Polideportivo El Fango | 200 | Bilbao | |
| Béisbol Navarra | Instalaciones Deportivas El Soto | 200 | Pamplona | |
| Pamplona | Instalaciones Deportivas El Soto | 200 | Pamplona | |
| Viladecans | Estadi Olimpic de Viladecans | 1,500 | Viladecans |