The 2016 Delray Beach International Tennis Championships was a professional men's tennis tournament played on hard courts. It was the 24th edition of the tournament, and was part of the World Tour 250 series of the 2016 ATP World Tour. It took place in Delray Beach, United States between 15 February and 21 February 2016.
| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Kevin Anderson | 14 | 1 | |||
 Australia | Bernard Tomic | 20 | 2 | ||
| Ivo Karlović | 26 | 3 | |||
| Grigor Dimitrov | 27 | 4 | |||
 France | Jérémy Chardy | 28 | 5 | ||
| Steve Johnson | 29 | 6 | |||
| Donald Young | 48 | 7 | |||
| France | Adrian Mannarino | 49 | 8 |
The following players received wildcards into the main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Malek Jaziri
Milos Raonic (right adductor injury) →replaced by 
Austin Krajicek
Mikhail Kukushkin (leg injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Bob Bryan | Mike Bryan | 11 | 1 | |||
| Raven Klaasen | Rajeev Ram | 53 | 2 | |||
| Treat Huey |  Belarus | Max Mirnyi | 65 | 3 | ||
| Eric Butorac | Scott Lipsky | 84 | 4 |
The following pairs received wildcards into the main draw:
The following pair received entry as alternates:
Steve Johnson (shoulder injury) Mikhail Kukushkin (leg injury)See main article: article and 2016 Delray Beach International Tennis Championships – Singles.
Sam Querrey defeated Rajeev Ram 6–4, 7–6(8–6)See main article: article and 2016 Delray Beach International Tennis Championships – Doubles.
Oliver Marach / Fabrice Martin defeated Bob Bryan / Mike Bryan 3–6, 7–6(9–7), [13–11]
