| Date: | 5–10 September |
| Edition: | 19th |
| Surface: | Clay |
| Location: | Seville, Spain |
| Champs: |  Casper Ruud |
| Champd: |  Íñigo Cervantes / Oriol Roca Batalla |
The 2016 Copa Sevilla was a professional tennis tournament played on clay courts. It was the 19th edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Seville, Spain between 5 and 10 September 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Íñigo Cervantes | 75 | 1 | |
 Austria | Gerald Melzer | 88 | 2 | |
 Japan | Taro Daniel | 101 | 3 | |
| Spain | Daniel Gimeno Traver | 118 | 4 | |
 Slovakia | Andrej Martin | 124 | 5 | |
 Belgium | Arthur De Greef | 138 | 6 | |
| Spain | Rubén Ramírez Hidalgo | 148 | 7 | |
| Spain | Enrique López Pérez | 177 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw with a protected ranking:
The following players received entry from the qualifying draw:
Pol Toledo Bagué
Christopher O'Connell Casper RuudThe following player entered as a lucky loser:
See main article: 2016 Copa Sevilla – Singles.
Casper Ruud def. Taro Daniel, 6–3, 6–4.See main article: 2016 Copa Sevilla – Doubles.
Íñigo Cervantes / Oriol Roca Batalla def. Ariel Behar / Enrique López Pérez, 6–2, 6–5 RET.