| Date: | 15–21 August |
| Edition: | 4th |
| Before Name: | Maserati Challenger |
| Draw: | 32S/11D |
| Surface: | Clay |
| Prize Money: | €35,000+H |
| Location: | Meerbusch, Germany |
| Champs: | Florian Mayer |
| Champd: |  Mikhail Elgin /  Andrei Vasilevski |
| After Name: | Bucher Reisen Tennis Grand Prix |
The 2016 Cittadino Challenger was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Meerbusch, Germany, between 15 and 21 August 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Florian Mayer | 94 | 1 | ||
 Spain | Roberto Carballés Baena | 98 | 2 | |
| Igor Sijsling | 112 | 3 | ||
 Canada | Steven Diez | 174 | 4 | |
 Poland | Jerzy Janowicz | 175 | 5 | |
| Spain | Jordi Samper-Montaña | 211 | 6 | |
 Brazil | André Ghem | 254 | 7 | |
| Belarus | Uladzimir Ignatik | 259 | 8 |
The following players received wildcards into the singles main draw:
Aliaksandr Prudnikau Nicola KuhnThe following players received entry from the qualifying draw:
Daniel Cox Andrei Vasilevski Mikhail ElginSee main article: 2016 Cittadino Challenger – Singles.
See main article: 2016 Cittadino Challenger – Doubles.
Mikhail Elgin / Andrei Vasilevski def. 
Sander Gillé / Joran Vliegen, 7–6(8–6), 6–4