| Champ: |  Kenny de Schepper |
| Runner: |  Marco Cecchinato |
| Score: | 2–6, 7–6(7–0), 7–5 |
| Type: | singles doubles |
See main article: 2016 Città di Como Challenger. Andrey Kuznetsov was the defending champion but chose not to defend his title.
Kenny de Schepper won the title after defeating Marco Cecchinato 2–6, 7–6(7–0), 7–5 in the final.