| Champ: |  Paolo Lorenzi |
| Runner: | Matteo Donati |
| Score: | 6–3, 4–6, 7–6(9–7) |
| Type: | singles doubles |
See main article: 2016 Città di Caltanissetta. Elias Ymer was the defending champion but lost in the second round to Alessandro Giannessi.
Paolo Lorenzi won the title after defeating Matteo Donati 6–3, 4–6, 7–6(9–7) in the final.