| Champ: |  Karen Khachanov |
| Runner: |  Albert Ramos Viñolas |
| Score: | 6−7(4−7), 7−6(7−3), 6−3 |
| Edition: | 1st |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: article and 2016 Chengdu Open. This was the first edition of the tournament. Karen Khachanov won his first ATP World Tour title, defeating Albert Ramos Viñolas in the final, 6−7(4−7), 7−6(7−3), 6−3.
The top four seeds receive a bye into the second round.