| Date: | September 26 – October 2 |
| Edition: | 1st |
| Category: | World Tour 250 |
| Prize Money: | $840,915 |
| Draw: | 28S / 16D |
| Surface: | Hard / outdoor |
| Location: | Chengdu, China |
| Champs: |  Karen Khachanov[1] |
| Champd: | Raven Klaasen /  Rajeev Ram[2] |
The 2016 Chengdu Open was a men's tennis tournament played on outdoor hard courts. It was the inaugural edition of the Chengdu Open and part of the ATP World Tour 250 series of the 2016 ATP World Tour. It took place at the Sichuan International Tennis Center in Chengdu, China, from September 26 to October 2, 2016. Unseeded Karen Khachanov won the singles title.
See main article: 2016 Chengdu Open – Singles.
Karen Khachanov defeated 
Albert Ramos Viñolas, 6–7(4–7), 7–6(7–3), 6–3See main article: 2016 Chengdu Open – Doubles.
Rajeev Ram defeated Pablo Carreño Busta / 
Mariusz Fyrstenberg, 7–6(7–2), 7–5| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
 Austria | Dominic Thiem | 10 | 1 | ||
 Australia | Nick Kyrgios | 15 | 2 | ||
| Grigor Dimitrov | 21 | 3 | |||
| Spain | Feliciano López | 26 | 4 | ||
| Spain | Albert Ramos Viñolas | 32 | 5 | ||
 Serbia | Viktor Troicki | 33 | 6 | ||
| João Sousa | 34 | 7 | |||
 Italy | Paolo Lorenzi | 35 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Nicolás Almagro →replaced by Lu Yen-hsun
Jérémy Chardy →replaced by 
Diego Schwartzman Jordan Thompson Guido Pella →replaced by John Millman Jo-Wilfried Tsonga →replaced by Konstantin Kravchuk| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Raven Klaasen | Rajeev Ram | 31 | 1 | |||
 Colombia | Juan Sebastián Cabal | Colombia | Robert Farah | 54 | 2 | |
 United Kingdom | Dominic Inglot | Serbia | Nenad Zimonjić | 88 | 3 | |
| Spain | Pablo Carreño Busta | Poland | Mariusz Fyrstenberg | 105 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
Radek Štěpánek (illness)
