| Date: | 19 – 25 September |
| Edition: | 6th |
| Draw: | 32S / 16D |
| Surface: | Clay |
| Prize Money: | $50,000 |
| Location: | Santos, Brazil |
| Champs: |  Renzo Olivo |
| Champd: |  Sergio Galdós / Máximo González |
The 2016 Campeonato Internacional de Tenis de Santos was a professional tennis tournament played on clay courts. It was the sixth edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Santos, Brazil between 19 and 25 September 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Facundo Bagnis | 87 | 1 | |
 Brazil | Thiago Monteiro | 101 | 2 | |
| Brazil | Rogério Dutra Silva | 103 | 3 | |
| Argentina | Renzo Olivo | 116 | 4 | |
| Brazil | João Souza | 125 | 5 | |
| Argentina | Guido Andreozzi | 131 | 6 | |
| Argentina | Nicolás Kicker | 135 | 7 | |
| Argentina | Máximo González | 144 | 8 |
The following players received wildcards into the singles main draw:
Felipe Meligeni Alves Osni Junior Rafael Matos Thiago Seyboth WildThe following players received entry into the singles main draw with a protected ranking:
The following players received entry from the qualifying draw:
Oscar José Gutierrez Fabrício Neis Eduardo Dischinger Caio SilvaSee main article: 2016 Campeonato Internacional de Tenis de Santos – Singles.
Renzo Olivo def. Thiago Monteiro 6–4, 7–6(7–5).See main article: 2016 Campeonato Internacional de Tenis de Santos – Doubles.
Sergio Galdós / Máximo González def. Rogério Dutra Silva / Fabrício Neis 6–3, 5–7, [14–12].