| Champ: |  Victoria Azarenka |
| Runner: | Angelique Kerber |
| Score: | 6–3, 6–1 |
| Draw: | 30 |
| Seeds: | 8 |
See main article: 2016 Brisbane International.
Maria Sharapova was the defending champion, but withdrew before her first match due to a wrist injury.
Victoria Azarenka won her first title in almost 3 years, beating Angelique Kerber in the final, 6–3, 6–1.
The top two seeds receive a bye into the second round.