The 2016 Blu Panorama Airlines Tennis Cup was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Perugia, Italy between 13 and 19 June 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Brazil | Rogério Dutra Silva | 83 | 1 | |
 Spain | Roberto Carballés Baena | 111 | 2 | |
 Italy | Thomas Fabbiano | 112 | 3 | |
 Sweden | Elias Ymer | 125 | 4 | |
| Italy | Marco Cecchinato | 127 | 5 | |
 Colombia | Santiago Giraldo | 128 | 6 | |
 Argentina | Guido Andreozzi | 154 | 7 | |
| Argentina | Nicolás Kicker | 163 | 8 |
The following players received wildcards into the singles main draw:
The following player entered the main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as a lucky losers:
See main article: 2016 Blu Panorama Airlines Tennis Cup – Singles.
Nicolás Kicker def. Blaž Rola, 2–6, 6–3, 6–0See main article: 2016 Blu Panorama Airlines Tennis Cup – Doubles.
Rogério Dutra Silva / Andrés Molteni def. Nicolás Barrientos / Fabrício Neis, 7–5, 6–3