See main article: 2016 Australian Open. Martina Hingis and Leander Paes were the defending champions, but lost in the quarterfinals to Sania Mirza and Ivan Dodig.
Elena Vesnina and Bruno Soares won the title, defeating CoCo Vandeweghe and Horia Tecău in the final, 6–4, 4–6, [10–5].