| Date: | 8–14 February |
| Edition: | 19th |
| Category: | ATP World Tour 250 series |
| Prize Money: | $523,470 |
| Draw: | 28S / 16D |
| Surface: | Clay / outdoor |
| Location: | Buenos Aires, Argentina |
| Champs: |  Dominic Thiem |
| Champd: |  Juan Sebastián Cabal / Robert Farah |
| Main Name: | ATP Buenos Aires |
The 2016 Argentina Open was a men's tennis tournament played on outdoor clay courts. It was the 19th edition of the ATP Buenos Aires event, and part of the ATP World Tour 250 series of the 2016 ATP World Tour. It took place in Buenos Aires, Argentina, from 8 February through 14 February 2016. Fifth-seeded Dominic Thiem won the singles title.
See main article: 2016 Argentina Open – Singles.
Dominic Thiem defeated 
Nicolás Almagro 7–6(7–2), 3–6, 7–6(7–4)[1]See main article: 2016 Argentina Open – Doubles.
Juan Sebastián Cabal / Robert Farah defeated Íñigo Cervantes / 
Paolo Lorenzi 6–3, 6–0| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | $93,120 | $49,045 | $26,570 | $15,135 | $8,920 | $5,285 | $2,380 | $1,190 | ||
| Doubles | $28,290 | $14,870 | $8,060 | $4,610 | $2,700 | |||||
| Doubles prize money per team | ||||||||||
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Rafael Nadal | 5 | 1 | |
| Spain | David Ferrer | 6 | 2 | |
 France | Jo-Wilfried Tsonga | 9 | 3 | |
| John Isner | 12 | 4 | ||
| Austria | Dominic Thiem | 19 | 5 | |
| Italy | Fabio Fognini | 24 | 6 | |
 Ukraine | Alexandr Dolgopolov | 32 | 7 | |
| Pablo Cuevas | 36 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Aljaž Bedene →replaced by Nicolás Almagro Andreas Haider-Maurer →replaced by 
Guido Pella
Jack Sock →replaced by Daniel Muñoz de la Nava Fernando Verdasco (late withdrawal) →replaced by Facundo Argüello| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Colombia | Juan Sebastián Cabal | Colombia | Robert Farah | 51 | 1 | |
| Argentina | Máximo González |  Brazil | André Sá | 98 | 2 | |
| Spain | David Marrero | Frank Moser | 156 | 3 | ||
| Argentina | Guillermo Durán | Argentina | Leonardo Mayer | 157 | 4 |
The following pairs received wildcards into the main draw: