See main article: 2016–17 Women's EHF Champions League. This article describes the knockout stage of the 2016–17 Women's EHF Champions League.
The top four placed teams from each of the two main round groups advanced to the knockout stage.
| Group | width=200 | First place | width=200 | Second place | width=200 | Third place | width=200 | Fourth place |
|---|---|---|---|---|---|---|---|---|
| 1 |  HC Vardar |  FTC-Rail Cargo Hungaria |  Buducnost |  Metz Handball | ||||
| 2 | Győri Audi ETO KC |  Larvik HK |  CSM București | Midtjylland |
The first-placed team of each group faced the fourth-placed team, and the second-placed team played against the third-placed team from the other group. After that a draw was held to determine the pairings for the final four.
|}
Vardar won 54–50 on aggregate.----Győri ETO won 59–54 on aggregate.----CSM București won 57–51 on aggregate.----Buducnost won 66–47 on aggregate.
The final four was held at the László Papp Budapest Sports Arena in Budapest, Hungary on 6 and 7 May 2017.[1]
The draw was held on 18 April 2017 at 13:00 in Budapest, Hungary.[2] [3] [4]
----