| EHF Challenge Cup | |
| Year: | 2016–17 |
| Sport: | Handball |
| Teams: | 32 |
| Champions: | Sporting CP |
| Runners-Up1: | Potaissa Turda |
| Top Scorer: | Georgică Cîntec (48 goals) |
| Previous: | 2015–16 |
| Next: | 2017–18 |
The 2016–17 EHF Challenge Cup was the 20th edition of the European Handball Federation's third-tier competition for men's handball clubs, which was won by Sporting CP running from 19 November 2016 to 27 May 2017.
| Round 3 | |||
|---|---|---|---|
| HC Visé BM | RK Vogošća Poljine Hills | HC Lokomotiv Varna | HC Dobrudja |
| A.S.S. Spes | Cambridge HC | A.C. Doukas | |
| Valur | Hapoel Ashdod | Ramat Hashron "S.G.S." HC | A.S.D. Romagna Handball |
| KH Kastrioti | Klaipeda Dragunas | Handball Esch | HB Dudelange |
| PGU-Kartina TV Tiraspol | Riviera-SSSH-2 | RK Pelister | RK Partizan 1949 |
| JMS Hurry-Up | Haslum Handballklubb | Sporting CP | AHC Potaissa Turda |
| RK Sloga Požega | RK Partizan | TSV St. Otmar St. Gallen | HKM Sala |
| MSK Povazska Bystrica | Göztepe SK | Tasova Yibo SK | HC ZNTU-ZAB Zaporizhzhia |
All draws held at the European Handball Federation headquarters in Vienna, Austria.
| Round | Draw date | First leg | Second leg |
|---|---|---|---|
| Round 3 | 19 July 2016 | 19–20 November 2016 | 26–27 November 2016 |
| Last 16 | 29 November 2016 | 18–19 February 2017 | 25–26 February 2017 |
| Quarter-final | 23 February 2017 | 19–20 March 2017 | 26–27 March 2017 |
| Semi-finals | 23–24 April 2017 | 30 April–1 May 2017 | |
| Finals | 14–15 May 2017 | 21–22 May 2017 |
Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into last 16.|}
Teams listed first played the first leg at home. Some teams agreed to play both matches in the same venue. Bolded teams qualified into quarter-finals.|}
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