| Season: | 2016–17 |
| Continentalcup1: | EHF Champions League |
| Continentalcup1 Qualifiers: | Atlético Guardés |
| Continentalcup2: | EHF Cup |
| Continentalcup2 Qualifiers: | Bera Bera |
| Continentalcup3: | EHF Challenge Cup |
| Continentalcup3 Qualifiers: | Rocasa G.C. ACE, Rincón Fertilidad Málaga |
| League Topscorer: | Silvia Arderíus, 198 |
| Nextseason: | 2017–18 |
The División de Honor Femenina 2016–17, or Liga Loterías 2016-17 after sponsorship of Loterías y Apuestas del Estado, was the 60th season of women's handball top flight in Spain since its establishment. Mecalia Atlético Guardés won their first División de Honor title ever. The season began on 10 September, 2016 and the last matchday was played on 27 May, 2017. A total of 14 teams took part the league, 12 of which had already contested in the 2015–16 season, and two of which were promoted from the División de Plata 2015–16.
Atlético Guardés won the championship by a two-points margin over 2nd team in the standings, Bera Bera.[1] Further, regarding to European competitions for 2017–18 season; Atlético Guardés qualified to EHF Champions League, Bera Bera. qualified to EHF Cup and Rocasa G.C. and Rincón Fertilidad Málaga to EHF Challenge Cup.
Teams promoted from 2015–16 División de Plata
Teams relegated to 2017–18 División de Plata
| Team | City | Stadium | Capacity | |
|---|---|---|---|---|
| Súper Amara Bera Bera | San Sebastián | Bidebieta | 1,000 | |
| Rocasa Gran Canaria ACE | Telde | Antonio Moreno | 800 | |
| Mecalia Atl. Guardés | A Guarda | A Sangriña | 1,500 | |
| Helvetia Alcobendas | Alcobendas | Los Sueños | 1,000 | |
| Godoy Maceira Porriño | O Porriño | Polideportivo Municipal | 1,600 | |
| Prosetecnisa Zuazo | Barakaldo | Lasesarre | 2,576 | |
| Aula Valladolid | Valladolid | Huerta del Rey | 3,500 | |
| Canyamelar Valencia | Valencia | El Cabanyal | 1,200 | |
| Rincón Fertilidad Málaga | Málaga | Carranque | 1,500 | |
| Esencia 27 ULE CLEBA León | León | Palacio de los Deportes | 6,500 | |
| Elche Mustang | Elche | Poliesportiu de Carrús | 800 | |
| KH-7 Granollers | Granollers | Palau d'Esports | 5,685 | |
| Base Villaverde | Madrid | Plata y Castañar | 1,100 | |
| Mavi Nuevas Tecnologías | Gijón | La Arena | 1,500 |
| Rank | Name[2] | Team | Goals | |||
|---|---|---|---|---|---|---|
| 1 |  Silvia Arderíus | Aula Valladolid | 198 | 26 | 7.62 | |
| 2 | Sara Gil de la Vega | Godoy Maceira Porriño | 191 | 26 | 7.35 | |
| 3 | Nerea Nieto | Base Villaverde | 170 | 23 | 7.39 | |
| 4 | Patricia Alonso | Canyamelar Valencia | 168 | 26 | 6.46 | |
| 5 | Almudena Rodríguez | Rocasa G.C. ACE | 142 | 24 | 5.92 | |
| 6 | Laura Hernández | Elche Mustang | 138 | 25 | 5.52 | |
| 7 | Ivet Musons | Elche Mustang | 135 | 21 | 6.43 | |
| 8 | Amaia González de Garibay | Aula Valladolid | 133 | 26 | 5.12 | |
| 9 | África Sempere | Mecalia Atl. Guardés | 131 | 25 | 5.24 | |
| 10 | María Luján | Rocasa G.C. ACE | 131 | 26 | 5.04 |