| Champ: |  Venus Williams |
| Runner: |  Garbiñe Muguruza |
| Score: | 6–3, 3–0, ret. |
| Type: | singles doubles |
| Before Name: | Wuhan Open – Singles |
| After Name: | Wuhan Open – Singles |
See main article: 2015 Wuhan Open.
Venus Williams won the singles tennis title at the 2015 Wuhan Open after Garbiñe Muguruza retired in the final, with the scoreline at 6–3, 3–0. Williams saved a match point en route to the title, in the semifinals against Roberta Vinci.
Petra Kvitová was the defending champion, but lost to Vinci in the third round.
The top eight seeds received a bye into the second round.