| Date: | 16 November – 22 November |
| Edition: | 11th |
| Surface: | Clay |
| Location: | Montevideo, Uruguay |
| Champs: |  Guido Pella |
| Champd: |  Andrej Martin / Hans Podlipnik Castillo |
The 2015 Uruguay Open is a professional tennis tournament played on clay courts. It is the eleventh edition of the tournament, and it is part of the 2015 ATP Challenger Tour. It took place in Montevideo, Uruguay between November 16 and November 22, 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Pablo Cuevas | 40 | 1 | ||
| Argentina | Diego Schwartzman | 72 | 2 | |
| Argentina | Guido Pella | 73 | 3 | |
 Spain | Íñigo Cervantes | 105 | 4 | |
 United Kingdom | Kyle Edmund | 110 | 5 | |
| Argentina | Facundo Argüello | 124 | 6 | |
| Argentina | Carlos Berlocq | 127 | 7 | |
| Argentina | Horacio Zeballos | 134 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Andrea Collarini Guillermo Durán Juan Ignacio Galarza
Orlando LuzSee main article: article and 2015 Uruguay Open – Singles.
Guido Pella def. Íñigo Cervantes 7–5, 2–6, 6–4[1]See main article: article and 2015 Uruguay Open – Doubles.
Andrej Martin / Hans Podlipnik Castillo def. Marcelo Demoliner / Gastão Elias 6–4, 3–6, [10–6]