| Champ: |  Jack Sock |
| Runner: | Sam Querrey |
| Score: | 7–6(11–9), 7–6(7–2) |
| Type: | singles doubles |
See main article: 2015 U.S. Men's Clay Court Championships. Fernando Verdasco was the defending champion, but lost to Sam Querrey in the semifinals.
Jack Sock won his first ATP singles title, defeating Querrey in the final, 7–6(11–9), 7–6(7–2).
The top four seeds receive a bye into the second round.
See also: 1. 
Feliciano López (quarterfinals)
See also: 2. Roberto Bautista Agut (second round)
See also: 3. Kevin Anderson (semifinals)
See also: 4. John Isner (second round)
See also: 5. 
Santiago Giraldo (quarterfinals)
See also: 6. Fernando Verdasco (semifinals)
See also: 7. 
Jérémy Chardy (quarterfinals)
See also: 8. Sam Querrey (final)