The 2015 U.S. Men's Clay Court Championships (also known as the Fayez Sarofim & Co. U.S. Men's Clay Court Championships for sponsorship purposes) was a tennis tournament played on outdoor clay courts. It was the 47th edition of the U.S. Men's Clay Court Championships, and an ATP World Tour 250 event on the 2015 ATP World Tour. It took place at River Oaks Country Club in Houston, Texas, United States, from April 6 through April 12, 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Feliciano López | 12 | 1 | |
| Spain | Roberto Bautista Agut | 15 | 2 | |
| Kevin Anderson | 17 | 3 | ||
| John Isner | 24 | 4 | ||
 Colombia | Santiago Giraldo | 31 | 5 | |
| Spain | Fernando Verdasco | 34 | 6 | |
 France | Jérémy Chardy | 38 | 7 | |
| Sam Querrey | 42 | 8 |
The following players received wildcards into the main draw:
The following players received entry via the qualifying draw:
Gaël Monfils →replaced by Go Soeda
Bernard Tomic →replaced by Tim Smyczek
Paolo Lorenzi Marinko Matosevic (left foot injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Bob Bryan | Mike Bryan | 2 | 1 | |||
| Eric Butorac | Australia | Sam Groth | 64 | 2 | ||
 Sweden | Robert Lindstedt |  Austria | Jürgen Melzer | 72 | 3 | |
 Poland | Mariusz Fyrstenberg |  Mexico | Santiago González | 81 | 4 |
The following pair received wildcards into the doubles main draw:
The following pairs received entry as alternates:
Ryan Harrison (right hip injury) Marinko Matosevic (left foot injury) Santiago González (right hamstring injury)See main article: 2015 U.S. Men's Clay Court Championships – Singles.
Jack Sock defeated Sam Querrey, 7–6(11–9), 7–6(7–2)See main article: 2015 U.S. Men's Clay Court Championships – Doubles.
Ričardas Berankis / 
Teymuraz Gabashvili defeated Treat Huey / Scott Lipsky, 6–4, 6–4
