See main article: 2015 San Luis Open Challenger Tour.
| Champ: |  Guido Pella |
| Runner: |  James McGee |
| Score: | 6–3, 6–3 |
| Type: | men |
| Before Name: | San Luis Potosí Challenger |
Paolo Lorenzi was the defending champion, but lost in the semifinals.
Guido Pella won the title, defeating James McGee in the final, 6–3, 6–3.