The 2015 San Luis Open Challenger Tour was a professional tennis tournament played on hard courts. It was the 22nd edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 31 March and 5 April.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Russian Federation | Teymuraz Gabashvili | 80 | 1 | |
 Italy | Paolo Lorenzi | 87 | 2 | |
 Bosnia and Herzegovina | Damir Džumhur | 92 | 3 | |
 Australia | James Duckworth | 97 | 4 | |
| Italy | ||||
 Spain | Adrián Menéndez Maceiras | 126 | 6 | |
| Austin Krajicek | 146 | 7 | ||
 Argentina | Horacio Zeballos | 148 | 8 |
The following players received wildcards into the singles main draw:
Mauricio Astorga Daniel Garza Manuel Sánchez Tigre HankThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following player received entry as an alternate:
See main article: 2015 San Luis Open Challenger Tour – Singles.
Guido Pella def. 
James McGee, 6–3, 6–3See main article: 2015 San Luis Open Challenger Tour – Doubles.
Guillermo Durán / Horacio Zeballos def. 
Sergio Galdós / Guido Pella, 7–6(7–4), 6–4
