| Champ: |  Novak Djokovic |
| Runner: | Roger Federer |
| Score: | 6–4, 6–3 |
See main article: 2015 Italian Open (tennis).
Defending champion Novak Djokovic defeated Roger Federer in the final, 6–4, 6–3 to win the men's singles tennis title at the 2015 Italian Open. It was Djokovic's fourth Italian Open title, the second-most of all-time behind Rafael Nadal. This is notable for being the only clay court final contested between Djokovic and Federer. It was Federer's fourth runner-up finish at the Italian Open (following defeats to Félix Mantilla in 2003 and to Nadal in 2006 and 2013), and his career-best finish at the event.
The top eight seeds receive a bye into the second round.