| Champ: |  Dominic Thiem |
| Runner: |  Leonardo Mayer |
| Score: | 6–7(8–10), 7–5, 7–6(7–2) |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: article and 2015 Open de Nice Côte d'Azur. Ernests Gulbis was the defending champion, but lost to Dominic Thiem in the quarterfinals.
Thiem went on to win his first ATP title, defeating Leonardo Mayer in the final, 6–7(8–10), 7–5, 7–6(7–2).
The top four seeds receive a bye into the second round.