The 2015 Open de Nice Côte d'Azur was a men's tennis tournament played on outdoor clay courts. It was the 31st edition of the Open de Nice Côte d'Azur and part of the ATP World Tour 250 series of the 2015 ATP World Tour. It took place at the Nice Lawn Tennis Club in Nice, France, from 17 May through 23 May 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | ||||
| John Isner | 17 | 2 | ||
| Ernests Gulbis | 22 | 3 | ||
 Argentina | Leonardo Mayer | 25 | 4 | |
 Australia | Bernard Tomic | 27 | 5 | |
| Australia | Nick Kyrgios | 30 | 6 | |
| Jack Sock | 33 | 7 | ||
| Argentina | Juan Mónaco | 36 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Simone Bolelli →replaced by Dušan Lajović
Guillermo García López →replaced by James Duckworth
Martin Kližan →replaced by Benoît Paire Thanasi Kokkinakis →replaced by Frances Tiafoe Diego Schwartzman →replaced by Alexandr Dolgopolov Gilles Simon →replaced by Quentin Halys| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Jean-Julien Rojer |  Romania | Horia Tecău | 25 | 1 | ||
 Canada | Daniel Nestor |  Austria | Alexander Peya | 34 | 2 | |
| Eric Butorac | Australia | Sam Groth | 74 | 3 | ||
| Spain | David Marrero |  Pakistan | Aisam-ul-Haq Qureshi | 82 | 4 |
The following pairs received wildcards into the doubles main draw:
Dominic Thiem defeated Leonardo Mayer, 6–7(8–10), 7–5, 7–6(7–2)
Michael Venus defeated Jean-Julien Rojer / Horia Tecău, 7–6(7–4), 2–6, [10–8]
