See main article: 2015 Open Sud de France.
Gaël Monfils was the defending champion, but lost to Richard Gasquet in the semifinals.
Gasquet went on to win the title, defeating Jerzy Janowicz in the final, 3–0, ret.
The first four seeds received a bye into the second round.
See also: 1. 
Gaël Monfils (semifinals)
See also: 2. Gilles Simon (quarterfinals)
See also: 3. Philipp Kohlschreiber (quarterfinals)
See also: 4. Richard Gasquet (champion)
See also: 5. 
Jerzy Janowicz (final, retired due to illness)
See also: 6. 
Denis Istomin (quarterfinals)
See also: 7. João Sousa (semifinals)
See also: 8. Jan-Lennard Struff (first round)
See also: 1. 
Steve Darcis (qualified)
See also: 2. Alexander Zverev (qualifying competition)
See also: 3. 
Nikoloz Basilashvili (qualified)
See also: 4. 
Taro Daniel (qualified)
See also: 5. 
Jürgen Zopp (qualified)
See also: 6. Enzo Couacaud (qualifying competition)
See also: 7. 
Thomas Fabbiano (qualifying competition)
See also: 8. Mathias Bourgue (first round)