| Champ: |  Andy Murray |
| Runner: |  Rafael Nadal |
| Score: | 6–3, 6–2 |
See main article: 2015 Mutua Madrid Open.
Andy Murray defeated the two-time defending champion Rafael Nadal in the final, 6–3, 6–2 to win the men's singles tennis title at the 2015 Madrid Open. It was his second title in as many weeks.
The top eight seeds receive a bye into the second round.