| Date: | 26–31 October |
| Edition: | 6th |
| Draw: | 32S / 16D |
| Surface: | Hard |
| Prize Money: | $100,000 |
| Champs: | Thiemo de Bakker |
| Champd: | Thiemo de Bakker / Mark Vervoort |
| Before Year: | 1996 |
The 2015 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Monterrey, Mexico from 26 to 31 of October 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Dominican Republic | Víctor Estrella Burgos | 64 | 1 | |
 Italy | Paolo Lorenzi | 71 | 2 | |
| Austin Krajicek | 96 | 3 | ||
| Bjorn Fratangelo | 129 | 4 | ||
| Thiemo de Bakker | 141 | 5 | ||
| Dennis Novikov | 147 | 6 | ||
 Spain | Jordi Samper-Montaña | 185 | 7 | |
 Ecuador | Giovanni Lapentti | 213 | 8 |
The following players received wildcards into the singles main draw:
The following player entered the singles main draw with a protected ranking:
Dennis NevoloThe following player entered the main draw as an alternate:
The following players received entry from the qualifying draw:
Luis Eduardo Morfin Friebel Luis Patiño
Alexandre Tsuchiya
Kaichi UchidaSee main article: 2015 Monterrey Challenger – Singles.
Víctor Estrella Burgos 7–6(7–1), 4–6, 6–3See main article: 2015 Monterrey Challenger – Doubles.
Paolo Lorenzi / Fernando Romboli by walkover.