| Champ: |  Serena Williams |
| Runner: |  Carla Suárez Navarro |
| Score: | 6–2, 6–0 |
| Draw: | 96 |
| Seeds: | 32 |
| Main Name: | Miami Masters |
| Before Name: | Sony Open Tennis – Women's singles |
| After Name: | Miami Open – Women's singles |
See main article: 2015 Miami Open.
Two-time defending champion Serena Williams defeated Carla Suárez Navarro in the final, 6–2, 6–0 to win the women's singles tennis title at the 2015 Miami Open. It was her record-extending eighth Miami Open title.
All seeds receive a bye into the second round.
