| Champ: |  Kei Nishikori |
| Runner: | Kevin Anderson |
| Score: | 6–4, 6–4 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | U.S. National Indoor Tennis Championships |
See main article: 2015 Memphis Open.
Kei Nishikori was the two-time defending champion and successfully defended his title, defeating Kevin Anderson 6–4, 6–4 in the final.
The top four seeds receive a bye into the second round.
See also: 1. 
Filip Krajinović (qualifying competition, lucky loser)
See also: 2. 
Adrián Menéndez Maceiras (second round)
See also: 3. 
Denis Kudla (qualified)
See also: 4. 
Victor Hănescu (qualifying competition)
See also: 5. 
Thanasi Kokkinakis (qualified)
See also: 6. Michael Russell (second round)
See also: 7. Austin Krajicek (qualified)
See also: 8. Ryan Harrison (qualified)