| Date: | 20–26 April |
| Edition: | 5th |
| Draw: | 32S / 16D |
| Surface: | Hard |
| Prize Money: | $100,000+H |
| Location: | Guadalajara, Mexico |
| Champs: |  Rajeev Ram |
| Champd: | Austin Krajicek / Rajeev Ram |
The 2015 Jalisco Open was a professional tennis tournament played on hard courts. It was the fifth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Guadalajara, Mexico between 20 and 26 April 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Adrián Menéndez Maceiras | 115 | 1 | |
 Colombia | Alejandro Falla | 116 | 2 | |
| Austin Krajicek | 121 | 3 | ||
| Ryan Harrison | 126 | 4 | ||
 Poland | Michał Przysiężny | 142 | 5 | |
| Denis Kudla | 150 | 6 | ||
 Australia | John-Patrick Smith | 155 | 7 | |
| Rajeev Ram | 185 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Henrique Cunha
Mauricio EchazúSee main article: 2015 Jalisco Open – Singles.
Rajeev Ram def. Jason Jung, 6–1, 6–2[1]See main article: 2015 Jalisco Open – Doubles.
Austin Krajicek / Rajeev Ram def. Marcelo Demoliner / 
Miguel Ángel Reyes-Varela, 7–5, 4–6, [10–6]