| Date: | 14 November – 21 November |
| Edition: | 20th |
| Surface: | Hard |
| Location: | Champaign, Illinois, United States |
| Champs: | Henri Laaksonen |
| Champd: | David O'Hare /  Joe Salisbury |
The 2015 JSM Challenger of Champaign–Urbana was a professional tennis tournament played on hard courts. It was the twentieth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Champaign, Illinois, United States between November 14 and November 21, 2015.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Tunisia | Malek Jaziri | 97 | 1 | |
| Austin Krajicek | 101 | 2 | ||
| Ryan Harrison | 108 | 3 | ||
 Australia | James Duckworth | 116 | 4 | |
 Colombia | Alejandro Falla | 118 | 5 | |
| Australia | John-Patrick Smith | 125 | 6 | |
| Bjorn Fratangelo | 130 | 7 | ||
| Blaž Rola | 132 | 8 |
The following players received wildcards into the singles main draw:
Jared Hiltzik Michael Mmoh Dennis Nevolo Noah RubinThe following players received entry from the qualifying draw:
See main article: article and 2015 JSM Challenger of Champaign–Urbana – Singles.
Taylor Fritz 4–6, 6–2, 6–2See main article: article and 2015 JSM Challenger of Champaign–Urbana – Doubles.
Joe Salisbury def. Austin Krajicek / Nicholas Monroe 6–1, 6–4